Events in the game happen a few years after Fallout 3. No characters from that game appear, Hines says, "but you will eventually hear a little bit about the events" of that game. New Vegas is "a self-contained story. You don't have to have played the previous games to have any clue what's going on here."
At the game's outset, you get to customize your character by choosing gender, age, race, other attributes and skills. "You were a courier, and you were obviously carrying something that somebody wanted," Hines says. "Part of the story is finding out what you had and what they took."
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